The global pharmaceutical market reached a total value of US$1.6 trillion in 2023, according to Statista, up significantly from the US$888 billion seen just over a decade earlier in 2010.
Experienced and novice investors alike may want to consider pharmaceutical exchange-traded funds (ETFs) as a way to gain exposure to the top pharma companies. Like all ETFs, pharmaceutical ETFs are a good option for those who want to trade a set of assets in the pharmaceutical industry instead of focusing solely on individual pharmaceutical stocks.
The main advantage of a pharmaceutical ETF is the fact that it can provide exposure to an overarching sector, but still trades like a stock. Pharma ETFs also offer less market volatility and lower fees and expenses.
Big pharma ETFs
Many of these funds have diverse holdings across some of the most important sectors in the pharmaceutical industry, including pain therapeutics, oncology, vaccines and biotechnology. Data was gathered on August 2, 2024.
1. iShares US Pharmaceuticals ETF (ARCA:IHE)
Total assets under management: US$666.28 million
Created on May 5, 2006, this iShares ETF tracks some of the top US pharma companies. In total, the iShares US Pharmaceuticals ETF has 38 holdings, with the vast majority being large-cap stocks.
Of its holdings, Johnson & Johnson (NYSE:JNJ) and Eli Lilly (NYSE:LLY) are by far the largest portions in its portfolio, coming in at weightings of 23.94 percent and 20.78 percent, respectively. The next highest are Bristol-Myers Squibb (NYSE:BMY) at 4.92 percent, Viatris (NASDAQ:VTRS) and Pfizer (NYSE:PFE) at 4.8 percent.
2. VanEck Vectors Pharmaceutical ETF (NASDAQ:PPH)
Total assets under management: US$631.62 million
Established in late 2011, the VanEck Vectors Pharmaceutical ETF tracks the MVIS US Listed Pharmaceutical 25 Index. It has the capacity to provide big returns, even though there are some risks attached to the ETF. An analyst report indicates that investors looking for ‘tactical exposure’ to the pharma sector might consider this ETF as an investment option.
The ETF has 26 holdings, with the top five being Eli Lilly with a weight of 11.61 percent, Novo Nordisk (NYSE:NVO) at 9.27 percent, Johnson & Johnson at 6.35 percent, AbbVie (NYSE:ABBV) at 5.89 percent and Novartis (NYSE:NVS) at 5.22 percent.
3. Invesco Pharmaceuticals ETF (ARCA:PJP)
Total assets under management: US$284.92 million
The Invesco Pharmaceuticals ETF is primarily focused on providing exposure to US-based pharma companies. An analyst report states that this ETF chooses individual securities based on certain investment criteria, namely stock valuation and risk factors. Invesco changed the fund’s name from the Invesco Dynamic Pharmaceuticals ETF in August 2023.
This ETF was started on June 23, 2005, and currently tracks 23 companies. Its top holdings are AbbVie with a weight of 6.67 percent, Regeneron Pharmaceuticals (NASDAQ:REGN) at 6.14 percent, Amgen (NASDAQ:AMGN) at 6.11 percent, Johnson & Johnson at 6.08 percent and Pfizer at 5.92 percent.
4. SPDR S&P Pharmaceuticals ETF (ARCA:XPH)
Total assets under management: US$205.59 million
The SPDR S&P Pharmaceuticals ETF came into the market on June 19, 2006, and represents the pharmaceutical sub-industry sector of the S&P Total Markets Index. An analyst report for the ETF suggests that due to its narrow focus — which includes pharma giants that post ‘big returns’ during times of consolidation — it should not be considered for a long-term portfolio.
This pharma ETF tracks 44 holdings; its top five are Axsome Therapeutics (NASDAQ:AXSM) with a weight of 4.26 percent, Viatris at 4.26 percent, Intra-Cellular Therapies (NASDAQ:ITCI) at 4.18 percent, Bristol-Meyers Squibb at 4.15 percent and Pfizer at 3.99 percent.
5. KraneShares MSCI All China Health Care Index ETF (ARCA:KURE)
Total assets under management: US$39.04 million
The KraneShares MSCI All China Health Care Index ETF was launched in February 2018 and tracks an index of large- and mid-cap Chinese stocks in the healthcare sector, all weighted by market capitalization. According to an analyst report, the fund provides investors with ‘exposure to a relatively small slice of the Chinese economy.’
The ETF tracks 61 holdings, and its top five are Shenzhen Mindray Bio-Medical Electronics (SZSE:300760) at 8.52 percent, Jiangsu Hengrui Medicine (SHA:600276) at 7.3 percent, BeiGene (OTC Pink:BEIGF,HKEX:6160) at 5.57 percent, CSPC Pharmaceutical Group (OTC Pink:CSPCY,HKEX:1093) at 4.07 percent and Innovent Biologics (OTC Pink:IVBXF,HKEX:1801) at 3.80 percent.
Securities Disclosure: I, Melissa Pistilli, hold no investment interest in any of the companies mentioned in this article.